Reconstructing structure and function of a neuronal circuit

Reconstruction of interneurons that mediate a complex computation " It's the first time that we get the complete wiring diagram of an entire brain area in a vertebrate. This enables analyses that have not been possible before. " Rainer Friedrich Research Overview Research Areas Scientific Publications Awards & Honors Partnerships Research Groups Overview Epigenetics Quantitative Biology Neurobiology Former Group Leaders Technology Platforms Overview C. elegans Facility Cell Sorting (FACS) Computional Biology Facility for Advanced Imaging and Microscopy Functional Genomics Proteomics & Protein Analysis Education & Careers Overview PhD & MD-PhD Programs Postdoctoral Activities Teaching Open Positions Working at the FMI Equality & Diversity Living in Basel Alumni About Overview FMI at a Glance Organization & Leadership Scientific Advisory Board History Contact News & Events Overview News Resources Seminars & Events 2020 © FMI Basel Switzerland About this site Extranet (FMI only) - Reconstructing structure and function of a neuronal circuit The function of neuronal circuits is thought to be determined largely by specific connections between neurons. But this assumption has been difficult to test because the reconstruction of the synaptic connectivity of a neuronal circuit - its "wiring diagram" - is a major challenge. Researchers from the Friedrich lab now recorded neuronal activity throughout the olfactory bulb of a zebrafish larva and subsequently reconstructed all neurons and their synaptic connections.