Discovering new drugs with Darwin

Representation of assembly (light blue) that recognize and binds PD-L1 (yellow).
Representation of assembly (light blue) that recognize and binds PD-L1 (yellow).
Representation of assembly ( light blue ) that recognize and binds PD-L1 ( yellow ) . Chemists at the University of Geneva have developed a new technique for selecting assemblies of molecules, making it possible to find the best combinations for each protein to be combated quickly and cheaply. Our body must constantly defend itself against bacteria and viruses. It generates millions of different antibodies, which are selected to recognise the enemy and trigger the best possible immune response. Scientists use these antibodies to for therapeutic purposes to target proteins and disrupt their harmful. However, identifying the small molecules that will form the basis of the drug is a long and tedious process. Chemists at the University of Geneva , Switzerland, have developed a technique inspired by the theory of Darwinian evolution: amplifying the best combinations and generating diversity allows biology to find solutions to new problems.
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