Also dogs develop malignant lymphoma

(Image: Pixabay CC0) - A study conducted by scientists at the Institute of Oncology Research (IOR, affiliated with USI and a member of Bios+) in collaboration with researchers specialized in veterinary oncology at the Universities of Turin and Bologna, identified the most frequent mutations in diffuse large B-cell lymphoma (DLBCL), one of the most frequent tumors in both humans and dogs, opening new therapeutic opportunities. The study is published in Lab Animal, a monthly international scientific journal of Nature portfolio. Diffuse large B-cell lymphoma (DLBCL) is one of the most common cancers in both humans and dogs. However, despite improvements in outcome, the clinical response to the treatment remains often unpredictable, especially in dogs where death related to lymphoma is very frequent and the survival time is very low (approximately one year). Within this context human and canine DLBCL are very similar, indeed several molecules to treat human lymphomas, now approved by American and European regulatory agencies, have been tested in several canine clinical trials with positive results. However, it is fundamental to study the DLBCL pathogenesis in dogs to identify homologies and differences with the human counterpart. The discovery In the paper recently published in Lab Animal journal, where a collaboration between scientists at the Institute of Oncology Research (IOR, affiliated with USI and a member of Bios+) and researchers with expertise in veterinary comparative oncology at the Universities of Turin and Bologna was established, the most frequent mutations in canine DLBCL were identified, some of them had also a prognostic and potentially therapeutic significance.