The cells in the top row were treated with the fluoxetine-like molecule AKS466 and then infected with SARS-CoV-2. The cells at the bottom were only infected; more viral RNA is detectable in them (lighter dots).
The cells in the top row were treated with the fluoxetine-like molecule AKS466 and then infected with SARS-CoV-2. The cells at the bottom were only infected; more viral RNA is detectable in them (lighter dots) . Completely unexpectedly, the enzyme ceramidase emerges as a new target structure for the therapy of SARS-CoV-2 infections. This is reported by Würzburg researchers in "Cells". Fluoxetine, a common antidepressant, inhibits the SARS-CoV-2 coronavirus in cell cultures and in preparations from human lung tissue. This was demonstrated by researchers at Julius-Maximilians-Universität (JMU) Würzburg in the summer of 2020. However, the mechanism of this inhibition was utterly unclear, so the teams continued their research.
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