In what is known as pseudouridylation, an RNA module in the long ribosomal RNA chain (rRNA; at right) is modified This process is triggered by a short snoRNA (at left), which guides the modifying enzyme to the selected RNA base of the rRNA. The flash of light shows the enzyme-catalysed conversion of the selected uridine nucleoside into a pseudouridine nucleoside. Both modules are depicted in their biochemical structure. |
In what is known as pseudouridylation, an RNA module in the long ribosomal RNA chain (rRNA; at right) is modified This process is triggered by a short snoRNA (at left), which guides the modifying enzyme to the selected RNA base of the rRNA. The flash of light shows the enzyme-catalysed conversion of the selected uridine nucleoside into a pseudouridine nucleoside. Both modules are depicted in their biochemical structure. Research group Ed Hurt - Ribosomes are the nanomachines of the cell whose task is the correct synthesis of proteins. Researchers at the Heidelberg University Biochemistry Center are studying the emergence of these "protein factories", also known as ribosomes. Led by Ed Hurt, they have decoded the special role of a heretofore unexplored biogenesis factor in the maturation of precursor ribosomes. The research results, obtained in close cooperation with colleagues of Ludwig Maximilian University of Munich, were published in the journal "Cell Reports".
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