Appearance of adhesion GPCRs (left) and functional principle of the NRS technique (right). The fruit fly nervous system reveals when, where, and how an adhesion GPCR is separated (bottom). Photo: Scholz & Langenhan et....
Appearance of adhesion GPCRs ( left ) and functional principle of the NRS technique ( right ). The fruit fly nervous system reveals when, where, and how an adhesion GPCR is separated ( bottom ). Photo: Scholz & Langenhan et. Adhesion GPCRs are a group of G protein-coupled receptors associated with many body functions and diseases. However, they have not yet been sufficiently studied to be used for therapies. Two research groups at the Rudolf Schönheimer Institute at the Faculty of Medicine at Leipzig University have now jointly developed a technology to change this. The novel NRS (NTF Release Sensor) technique captures unique molecular switch events of adhesion GPCRs that were previously hidden from researchers.
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