New insight into sensing and function of the bacterial lysate OM-85

Bacterial lysates are widely used in the clinic to minimize the pathologic consequences of respiratory infections. Our new study shows how one such lysate, OM-85, works on human myeloid cells to trigger an immunomodulatory gene circuit. Bellinzona, March 21, 2024 - OM-85 is a bacterial lysate commonly used in clinical practice to reduce duration and frequency of recurrent respiratory tract infections. Whereas some studies have addressed its regulatory effects  in vivo , the mechanisms of OM-85 sensing remain inadequately investigated. In a new study recently published in  Mucosal Immunology , led by prof. Greta Guarda at the Institute for Research in Biomedicine (IRB, affiliated to the Universitą della Svizzera italiana), in collaboration with OM-Pharma (Meyrin, Switzerland), Dr. med. Maurizio Bernasconi at Ente Ospedalierio Cantonale (EOC), and Oncolines (Netherlands), the researchers investigated the mechanisms of OM-85 sensing and function in the immune cells. Dr. Hanif Khameneh and colleagues showed that, in human immune cells, TLR2 and TLR4 orchestrate the response to OM-85.
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