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Tanycytes (white) capture Tau protein (red) circulating in the cerebrospinal fluid and transport it along their extensions/arms, which pass through brain tissue and come into contact with blood vessels (green), into which they release this protein, which is involved in Alzheimer's disease when it accumulates in the brain.

Sleep apnea affects nearly one billion people worldwide and causes repeated episodes of oxygen deprivation during the night, known as intermittent hypoxia. A study conducted by scientists from the University of Grenoble Alpes, Inserm, and Grenoble Alpes University Hospital, published today in the journal Science Advances , shows that these episodes reorganize the liver's biological clock, altering the daily rhythms of its metabolic activity.

In Paris, districts with more vegetation have a lower risk of death during periods of high heat, while highly mineralized areas with few green spaces and a high potential for urban heat islands are the most exposed. This is the finding of an international study conducted by Inserm, the Barcelona Institute for Global Health (ISGlobal) and the London School of Hygiene & Tropical Medicine, published on January 27 in the journal npj Urban Sustainability, based on data collected over nearly ten years, from 2008 to 2017.

Hypertension and diabetes are often associated, greatly increasing the risk of stroke and severe kidney damage. Researchers from Surrey (UK) and Lille (France), working in the "Multi-omics and pathophysiology of metabolic diseases" unit (Inserm/CNRS/Université de Lille/ CHU de Lille/Institut Pasteur Lille), have identified five biological pathways that explain why type 2 diabetes and hypertension coexist so frequently.

In the event of neuroinflammation, the brain has a rapid defense mechanism: tiny bone channels allow immune cells to pass directly from the cranial bone to the meninges. A recent study by Inserm, CNRS and Aix-Marseille University reveals that these channels are formed in the first few weeks of life, and that their structure can be remodeled to facilitate the passage of immune cells.

Histological markings of an epileptic mouse irradiated with MRT; neurons are shown in blue, astrocytes in violet © Samalens et al, 2025, Epilepsia/Inserm Researchers at Inserm and the Université Grenoble Alpes (UGA) have discovered a new therapeutic approach to drug-resistant epilepsy. Fractional administration of X-ray microbeams induces a significant reduction in the occurrence of seizures in treated animals over a 2-month period: the first evidence in favor of a clinical application.

Researchers from Inserm and Paris Cité University, involved in the CORIMUNO-19 study promoted by AP-HP and funded by the Fondation pour la Recherche Médicale and ANRS Maladies infectieuses émergentes (ANRS MIE), have identified biological indicators that can predict 3-month mortality in patients hospitalised for COVID-19 pneumonia.

A team of researchers from Hôpital Henri-Mondor AP-HP, Inserm, Université Paris-Est Créteil (UPEC) and the ComPaRe - Neurofibromatosis cohort, coordinated by Dr Laura Fertitta and Pr Pierre Wolkenstein, has developed the cNF-PUSH-D'oe questionnaire.this is the first questionnaire to measure the stigma experienced by people with neurofibromatosis type 1 in relation to cutaneous neurofibromas.

Only a few animals in the world possess the ability to regenerate tissue, enabling them to regrow limb parts or whole limbs after amputation. In a study published in the journal PNAS , a research team from Inserm, the University of Montpellier and Montpellier University Hospital shows that laboratory-grown mouse embryos can only initiate regeneration of forelimb buds, such as the front legs, for an extremely short period: between 10.5 and 12.5 days after fertilization, when limb buds are just beginning to form.

following an acute coronary syndrome (ACS), the risk of recurrence of a major cardiovascular event (new infarction, coronary event or death) is particularly high. This is because some patients have residual or chronic inflammation for which there is currently no treatment.

A study by Inserm, in collaboration with the CNRS, the University of Grenoble Alpes (UGA), the Grenoble Alpes University Hospital (CHU), and the Barcelona Institute for Global Health (ISGlobal), published on December 9 in the The Lancet Planetary Health journal, suggests there may be an association between exposure in the third trimester of pregnancy to two synthetic phenols, methylparaben and bisphenol S, commonly found in everyday products (food, cosmetics, plastics, etc.), and questionnaire scores that could suggest behavioral disorders in children.

The presence of a compound present in cruciferous vegetables, indole-3-carbinol, is essential to make certain cancer treatments effective. Photo by Monika Borys / Unsplash It is a universally recognized truth that vegetables are good for your health. A study conducted by Institut Curie and Inserm reveals that the presence of a compound present in cruciferous vegetables, indole-3-carbinol, is essential to make certain cancer treatments effective.

Two researchers from Inserm and one researcher from INRAE contributed to a series of three articles published on 19 November in The Lancet on the health consequences of consuming ultra-processed foods. The 43 international scientists who signed this series of articles propose the implementation of public health measures to limit the use of ultra-processed foods and improve nutrition worldwide.

4D visualisation of the vascularisation of an entire kidney obtained using the multi-lens probe developed in this study. Veins are shown in blue and arteries in red. Colour variations indicate blood flow velocity: the brighter the colour, the faster the blood is flowing. The smallest vessels are less than 100 micrometres in diameter.

Consumption of plant-based products is associated with better cardiovascular health, provided they are of good nutritional quality and not or minimally processed. This is the finding of a research team from INRAE, Inserm, Sorbonne Paris Nord University and Cnam, based on analysis of health data from a cohort of 63,835 adults.

Astrocytes are found throughout the brain. Each astrocyte is in contact with several neurons and more than 100'000 synapses. A new study shows that, at the microscopic level, dozens of synapses from distinct neural circuits gather around a single specialized astrocyte structure called a leaflet, which is capable of detecting and integrating the activities of multiple synapses.

Molecules passing through the colon epithelium via specialized pathways (goblet cells). In red: the molecules transported (antigens); in blue: the epithelium. Institut Pasteur/Microbiome-Host Interactions/Clara Delaroque and Benoit Chassaing A study conducted in mice by scientists from the Institut Pasteur and Inserm reveals that maternal consumption of dietary emulsifiers can have a negative impact on the gut microbiota of their offspring.

Mouse skin structure after stretching, using histological staining. The scale bar corresponds to 100 micrometers. Darawan Tabtim-On and Renaud Leclère - Experimental Pathology Platform, Institut Curie What if vaccination could be administered by simple skin application rather than injection? A team of researchers from Inserm, Institut Curie, and King's College London investigated the impact of external mechanical constraints (skin stretching, friction, etc.) on skin impermeability in animals and humans.

With neonatal mortality on the increase in France, a new study by Inserm, Paris Cité University, Inrae, Paris Nord University and APHP, published on 16 September in BMJ Medicine , shows that it could be linked to socioeconomic inequalities. Using their social deprivation index adjusted for the perinatal period, the researchers observed that the risk of neonatal death is higher for mothers living in deprived municipalities.

In ICARUS-BREAST 01 study, more than half of the patients with metastatic breast cancer saw their disease reduce or disappear completely thanks to the treatment. In some cases, this response has now lasted for more than two years. Dr Barbara Pistilli, Head of the Breast Cancer Group at Gustave Roussy and Guillaume Montagnac, Inserm researcher, Head of Tumor Cell Dynamics unit, coordinated the study, the results of which have just been published in Nature Medicine.