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Institut national de la santé et de la recherche médicale (INSERM)


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Health - Pharmacology - 10.04.2024
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Respiratory allergies: newly discovered molecule plays a major role in triggering inflammation
Inflammation plays a major role in allergic diseases, affecting at least 17 million people in France, including 4 million asthmatics. One of the molecules that initiates this process in the respiratory tract has just been identified. This molecule, a member of the alarmin family, is a major therapeutic target for the development of new treatments for respiratory allergies.

Health - 20.03.2024
A study on the pre-COVID-19 health of French citizens to help decision-makers reduce the disease burden
A study on the pre-COVID-19 health of French citizens to help decision-makers reduce the disease burden
In order to implement suitable public health policies, it is crucial to know the health status of the population and its evolution over time. This knowledge is all the more important given the severe disruptions caused by the COVID-19 pandemic to healthcare systems worldwide.

Life Sciences - Health - 14.03.2024
Amyotrophic lateral sclerosis: a new avenue for improving patient diagnosis and follow-up
Amyotrophic lateral sclerosis: a new avenue for improving patient diagnosis and follow-up
Amyotrophic lateral sclerosis or Charcot's disease is a neurodegenerative disease that results in progressive paralysis and subsequent death. Diagnosing it is difficult and no curative treatment exists to date, making these challenges for research. In a new study, Inserm researcher Caroline Rouaux and her team at the Strasbourg Biomedical Research Centre (Inserm-Université de Strasbourg), in collaboration with researchers from Ludwig Maximilian University in Munich, CNRS and Sorbonne Université, show that electroencephalography could become a diagnostic and prognostic tool for the disease.

Health - Pharmacology - 11.03.2024
A promising vaccine against Nipah virus infection
A promising vaccine against Nipah virus infection
The WHO recently classified the Nipah virus (NiV) as one of the eight main emerging pathogens likely to cause major epidemics in the future. In a context where no treatment or vaccine is yet available, a team comprising researchers from Inserm (Unit 955-VRI) and from the Université Paris-Est Créteil (UPEC) is presenting the preclinical results of an innovative vaccine against this virus.

Life Sciences - Music - 06.03.2024
The brain mechanisms behind our desire to dance
Why does some music make us want to dance more than others? This is the question that a research team from Inserm and Aix-Marseille Université tried to answer by studying the desire to dance (also called the 'groove') and the brain activity of 30 participants who were asked to listen to music. Their findings show that the groove sensation is highest for a moderately complex rhythm and that the desire to move is reflected in the brain by an anticipation of the music's rhythm.

Health - Life Sciences - 26.02.2024
New discovery on iron metabolism improves anemia treatment
Anemia is a major public health problem worldwide, affecting around a third of the population. There are many causes of anemia, but the most common are a defect in the production of red blood cells, a lack of iron in the blood or genetic diseases such as thalassemia. A better understanding of iron metabolism is essential to improve management of the many patients affected.

Health - Life Sciences - 26.02.2024
Improving the treatment of anaemia thanks to a new discovery in iron metabolism
An essential component of the haemoglobin in red blood cells, iron is crucial to many biological processes - including the transport and storage of oxygen in the body. © Inserm/Claude Féo Anaemia is a major public health problem worldwide, affecting around one third of the population. Its causes are multiple, but the most common are a lack of red blood cell production, a lack of iron in the blood, and genetic diseases such as thalassaemia.

Health - Life Sciences - 20.02.2024
Obesity: opt for omega 3 fatty acids to prevent the associated risks
In yellow, microglia (immune cells of the brain) activated by the pro-inflammatory nature of a sunflower oil-enriched diet (fluorescence microscopy). Clara Sanchez/Inserm Obesity is a major public health problem, affecting around 650 million adults worldwide , and is often associated with systemic and cerebral inflammation as well as anxiety and cognitive disorders, such as memory deficits.

Health - Life Sciences - 19.02.2024
New cell senescence discoveries open up therapeutic avenues in fighting age-related diseases
An increase in glycerol kinase (GK) enzyme activity on its own is capable of halting cell proliferation and initiating a programme of senescence. The blue staining of the cells is a biomarker of senescence. This image shows cells overexpressing the GK enzyme. Khaled Tighanimine/team Mario Pende. Cell senescence is a physiological process that has been associated in many studies with age-related diseases.

Health - Pharmacology - 15.02.2024
New therapeutic avenues to improve ovarian cancer treatment
New therapeutic avenues to improve ovarian cancer treatment
By studying for the first time the effects of chemotherapy on certain cells in the tumor microenvironment , a team from the Institut Curie and Inserm, led by Dr. Fatima Mechta-Grigoriou, has taken a major step towards understanding the mechanisms of chemotherapy resistance in ovarian cancer patients.

Health - 13.02.2024
The consumption of certain food additive emulsifiers may increase the risk of cancer
The consumption of certain food additive emulsifiers may increase the risk of cancer
Emulsifiers are among the additives most widely used by the food industry, helping to improve the texture of food and extend its shelf life. Researchers from Inserm, INRAE, Université Sorbonne Paris Nord, Université Paris Cité and Cnam, as part of the Nutritional Epidemiology Research Team (CRESS-EREN), have undertaken to study the possible links between the dietary intake of food additive emulsifiers and the development of cancer.

Health - 31.01.2024
Type 2 diabetes: discovery of a new biological cardiovascular risk marker
Type 2 diabetes: discovery of a new biological cardiovascular risk marker
Scientists from Inserm, Université Paris Cité and CNRS at the Necker Enfants Malades Institute in Paris have identified a new prognostic marker for cardiovascular risk in people with type 2 diabetes (T2D). Led by Inserm researcher Nicolas Venteclef, the team has shown that the number of white blood cells circulating in the blood, as well as certain subtypes, is associated with stroke or myocardial infarction risk over the next ten years.

Health - Life Sciences - 16.01.2024
HIV: early treatment, one key to remission
HIV: early treatment, one key to remission
People living with HIV need to take antiretroviral treatment for life to prevent the virus from multiplying in their body. But some people, known as "post-treatment controllers,- have been able to discontinue their treatment while maintaining an undetectable viral load for several years. Starting treatment early could promote long-term control of the virus if treatment is discontinued.

Health - 19.12.2023
Leading causes of death in France in 2021
Leading causes of death in France in 2021
Inserm's Centre d'épidémiologie des causes médicales de décès (CépiDc-Inserm), the Direction de la recherche, des études et de l'évaluation des statistiques (DREES) and Santé Publique France are analyzing the medical causes of death of people living and dying in France in 2021. Two complementary studies, which present these results, are published jointly in études et Résultats (DREES) and in the Bulletin épidémiologique hebdomadaire (Santé publique France).

Health - 14.12.2023
Eating meals early could reduce cardiovascular risk
Freepik A study led by scientists from INRAE, the Barcelona Institute for Global Health, Inserm, and the Université Sorbonne Paris Nord, has revealed that the time at which we eat could influence our risk of developing cardiovascular disease. This study, carried out on a sample of over 100,000 people from the NutriNet-Santé cohort, followed between 2009 and 2022, suggests that eating a late first or last meal is associated with a higher risk of cardiovascular disease.

Health - Psychology - 13.12.2023
A new study sheds light on the link between childhood ADHD symptoms and physical health conditions
Attention-deficit hyperactivity disorder (ADHD) affects many children and is often accompanied by other conditions, such as metabolic disorders, asthma and dental caries. However, uncertainties remain as to the chronology of onset of such conditions, particularly when it comes to knowing which are linked with ADHD over time or, on the other hand, which increase the risk of developing ADHD symptoms.

Life Sciences - Health - 11.12.2023
Discovery of the role of a brain regulator involved in psychiatric illnesses
Contrary to all expectations, GluD1 - a receptor considered to be excitatory - has been shown in the brain to play a major role in controlling neuron inhibition. Given that alterations in the GluD1 gene are encountered in a certain number of neurodevelopmental and psychiatric disorders, such as autism (ASD) and schizophrenia, this discovery opens up new therapeutic avenues to combat the imbalances between excitatory and inhibitory neurotransmissions associated with these disorders.

Life Sciences - Health - 08.12.2023
The very first 3D map of the embryonic human head enables new insights into its development
The very first 3D map of the embryonic human head enables new insights into its development
3D light-sheet microscope image of a lacrimal gland of a tissue-cleared 12-week-old human embryo. The different elements of the gland were coloured using virtual reality software.

Health - Life Sciences - 08.12.2023
First 3D mapping in the embryo
Improving our knowledge of the development of the complex structures that make up the human head, and thus gaining a better understanding of the congenital anomalies that cause malformations: this is the challenge that a team of researchers from Inserm, CNRS and Sorbonne Université at the Institut de la vision, Université Claude Bernard Lyon 1 and Hospices civils de Lyon is well on the way to meeting.

Health - Pharmacology - 01.12.2023
Follow-up of patients cured of Ebola virus disease
Follow-up of patients cured of Ebola virus disease
Inserm press room - Institut national de la santé et de la recherche médicale press room Certain treatments to combat the Ebola virus, notably those based on monoclonal antibodies 1 , have increased the survival rate of patients suffering from the disease and are now recommended. Researchers from IRD, Inserm, ANRS Emerging Infectious Diseases and INRB have assessed, for the first time, the antibody response of survivors of the tenth Ebola epidemic in the Democratic Republic of Congo (DRC) who received specific anti-viral drugs.
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