news

Epidemics of Ebola virus disease occur periodically in several sub-Saharan African countries. Two vaccines have already received WHO prequalification against the Ebolavirus Zaire species. However, information on the long-term immune response to these vaccines is still insufficient. We need to consolidate our knowledge on this subject to continue developing the safest and most effective vaccination strategies possible, for both adults and children.

Age-related macular degeneration (AMD) is the leading cause of visual disability in people over 50 years of age. Age-related macular degeneration (AMD) is the leading cause of visual disability in people over 50 years of age. Improving the treatment offering for patients is a major challenge for research.

Nearly one in three cancers develops following chronic inflammation, whose origin remains unclear. In a new study, researchers from Inserm, CNRS, Université Claude-Bernard Lyon 1 and the Léon Bérard Centre at the Cancer Research Center of Lyon identified lymphocytes involved in the inflammatory processes and that are thought to be implicated in the generation of these cancers.

The ANRS DOXYVAC trial, promoted and funded by ANRS Emerging Infectious Diseases, and conducted by research teams from Inserm, AP-HP, Université Paris Cité and Sorbonne Université (France), shows that a rapid rollout of smallpox vaccination with MVA-BN ( Modified vaccine Ankara ) among HIV-positive men who have sex with men significantly reduces the risk of mpox by 99%.

Acute myeloid leukaemia is one of the deadliest cancers. Leukaemic stem cells responsible for the disease are highly resistant to treatment. A team from the University of Geneva (UNIGE), University Hospital of Geneva (HUG), and Inserm has made a breakthrough by identifying some of the genetic and energetic characteristics of these stem cells.

Phospho-ERK (red), Green Fluorescent Protein (cyan) and DAPI coimmunofluorescence on spleen sections from mice carrying a KRAS G12C endothelial mutation © Guillaume Canaud The teams of the translational medicine and targeted therapies unit of the Necker-Enfants Malades AP-HP hospital, Inserm, Paris Cité University within the Necker-Enfants Malades Institute, coordinated by professors Guillaume Canaud (Université Paris Cité, AP-HP) and Laurent Gu

Jannis Brandt Unsplash The intestinal immune system is an indispensable intermediary in the complex association between diet and metabolism: without it, the dietary fibers present in fruit and vegetables cannot play a proper part in regulating blood sugar levels in the body. Researchers at Inserm and Sorbonne University have now demonstrated that a certain type of immune cell is essential for the beneficial effect of dietary fibre on carbohydrate metabolism.

MRI image showing the reconstructed pulmonary valve (circled in red) that is closing perfectly 7 days after implantation. Fabien Kawecki/Inserm Researchers from Inserm have developed a pulmonary valve using human collagen. A device that could ultimately be a game-changer in the treatment of paediatric heart diseases, such as tetralogy of Fallot.

In France, 900 000 people have Alzheimer's disease or a related condition. The risk of developing Alzheimer's depends on genetic and environmental factors. Among these factors, various epidemiological studies suggest that the regular consumption of moderate amounts of caffeine slows age-related cognitive decline and the risk of developing the disease.

In France, 900,000 people suffer from Alzheimer's or a related disease. The risk of developing Alzheimer's disease depends on genetic and environmental factors. Among the latter, various epidemiological studies suggest that regular, moderate caffeine consumption slows age-related cognitive decline and the risk of developing Alzheimer's disease.

Ageing greatly increases the risk of ischaemic stroke. A team of researchers from Inserm, Caen-Normandy University Hospital and Université de Caen Normandie have looked at the role that immune cells known as central nervous system-associated macrophages (CAMs) could play in the neurological damage that occurs following a stroke.

Labeling of cytotoxic T lymphocytes (CD8 in red and the "residence" marker CD103 in green) lodged in the choroid plexus of a parasite-infected brain Toxoplasmosis is an infection caused by a parasite called Toxoplasma gondii ( T. gondii ). In over a third of the human population, this parasite establishes a chronic brain infection that can have serious consequences in people with weakened immunity.

The teams from the kidney transplantation department of Necker-Enfants Malades AP-HP hospital, Inserm and Paris Cité University, as part of the Paris Translational Research Center for Organ Transplantation (PARCC), coordinated by doctor Olivier Aubert and Professor Alexandre Loupy conducted a study on the benefit of liquid biopsy (cfDNA) as a technique for predicting kidney transplant rejection.

A ground-breaking study conducted by INSERM's Groupe de Recherches sur l'Alcool et les Pharmacodépendances (GRAP) opens up new therapeutic perspectives for the treatment of alcohol addiction with psilocybin, the active compound in hallucinogenic mushrooms. Published in the scientific journal Brain , their work confirms the potential of psilocybin to combat alcohol addiction, while shedding light on the molecule's hitherto unknown mechanisms of action.

After how long do women treated for breast cancer return to work? Until now, there has been little national data on this important aspect of the patient's care. A study carried out by researchers at Claude Bernard Lyon 1 University, Inserm, Gustave Eiffel University and Hospices civils de Lyon, based on data from the Assurance Maladie, has quantified this phenomenon, shedding light on the diversity of situations experienced by these women.

Scanning electron microscopy. Here we see how platelets (in blue/purple) attach to two tumour cells (in red) in a pre-clinical mouse model. Maria Jesus Garcia Leon (unit 1109 Inserm/Université de Strasbourg) What if our blood platelets , which play a major role in maintaining the integrity of our circulatory system, were not always on our side' Research teams from Inserm, Université de Strasbourg and the French Blood Establishment have studied their role in the process of metastasis formation.

How does exposure to air pollution affect the proper course of pregnancy and the development of the unborn child' A research team from Inserm and Université Grenoble Alpes investigated the potential effects on placental DNA of exposure to three major airborne pollutants. When comparing the data obtained from around 1 500 pregnant women, it observed that exposure to these pollutants during pregnancy was associated with epigenetic changes liable to alter the development of the foetus, particularly at the metabolic, immune and neurological levels.

How does exposure to air pollution during pregnancy affect the pregnancy and the development of the unborn child? A research team from Inserm and Grenoble Alpes University has investigated how placental DNA is modified by exposure to three major air pollutants. By comparing data obtained from almost 1,500 pregnant women, they were able to observe that exposure to these pollutants during pregnancy was associated with epigenetic modifications likely to alter fetal development, particularly at the metabolic, immune and neurological levels.

Human embryo compaction, an essential step in the first days of an embryo's development, is driven by the contractility of its cells. This is the finding of a team of scientists from CNRS, Institut Curie, Inserm, AP-HP and the Collège de France. Published in the 1 May edition of Nature, these results contradict the presupposed driving role of cell adhesion in this phenomenon and pave the way for improved assisted reproductive technology (ART) .

Emulsifiers are among the additives most widely used by the food industry, helping to improve the texture of food products and extend their shelf life. Researchers from Inserm, INRAE, Université Sorbonne Paris Nord, Université Paris Cité and Cnam, as part of the Nutritional Epidemiology Research Team (CRESS-EREN), studied the possible links between the dietary intake of food additive emulsifiers and the onset of type 2 diabetes between 2009 and 2023.