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Three men who had heart failure caused by the build-up of sticky, toxic proteins are now free of symptoms after their condition spontaneously reversed in an unprecedented case described by a team at UCL and the Royal Free Hospital. The condition, a form of amyloidosis affecting the heart, is progressive and has until now been seen as irreversible, with half of patients dying within four years of diagnosis.

The addition of 'trust' and 'distrust' buttons on social media, alongside standard 'like' buttons, could help to reduce the spread of misinformation, finds a new experimental study led by UCL researchers. Incentivising accuracy cut in half the reach of false posts, according to the findings published in eLife.

Symptoms of the neurological movement disorder, dystonia, which include muscle spasms, twisting of the body and tremors, arise from an impairment in spinal cord function, finds a new study in mice by UCL researchers. Many neurological conditions that involve involuntary muscle contractions have long been considered as diseases of the brain.

Professor Richard Gregory (UCL Biosciences) explains that pesticides and fertilisers are the single biggest cause of birds shocking decline across Europe and suggests how best to respond, writing in The Conversation. A trickle of studies warning that the enormous variety of living things on Earth is diminishing has turned into a flood.

People who are socially engaged when middle aged and beyond are 30-50% less likely to develop dementia later on, finds a new review of evidence led by UCL researchers. The narrative review, published in Nature Aging , summarises the observational, interventional and mechanistic evidence for social participation as a way to reduce dementia risk, from studies conducted across the globe, while also providing recommendations for how societies could collectively reduce dementia risk.

Adolescents who show signs of alcohol dependence are more likely to develop depression by their mid-20s, according to a new study led by UCL and University of Bristol researchers. Drinking large amounts of alcohol regularly, but with no signs of dependency, did not predict depression risk, according to the findings published in The Lancet Psychiatry .

Researchers from UCL, the UK Dementia Research Institute, Imperial College London and Newcastle University, are involved in a major new collaboration to develop a technology that could help identify people at risk of developing dementia by analysing their sleep patterns. Using a Sleep Analyzer tracking mat produced by technology company, Withings, the researchers created The Dementia Sleep Index - by comparing sleep patterns of people living with dementia to data that equates to 3.7million nights of sleep in the general population.

Five subtypes of heart failure that could potentially be used to predict future risk for individual patients have been identified in a new study led by UCL researchers. Heart failure is an umbrella term for when the heart is unable to pump blood around the body properly. Current ways of classifying heart failure do not accurately predict how the disease is likely to progress.

A cleft lip or palate arises from the combined effects of genes and inflammatory risk factors experienced during pregnancy, such as smoking or infections, finds a new study led by UCL researchers. The study, published in Nature Communications , has revealed for the first time how genetic and environmental factors come together to form a cleft lip or palate in a developing foetus.

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL. The study, published in Brain , follows up the teams' discovery in 2019 of the FAAH-OUT gene and the rare mutations that cause patient, Jo Cameron, to feel virtually no pain and never feel anxious or afraid.

Research led by UCL, in partnership with the MRC Laboratory of Molecular Biology (MRC LMB) and AstraZeneca, has identified a new compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the sort of damage seen in heart attack. The study, published in Nature , identified a chemical compound, named '1938', that activates the PI3K signalling pathway, and is involved in cell growth.

Credit holidays, which allowed borrowers to postpone their credit repayments during the pandemic, helped improve the mental health of those who used them finds Dr Jacques Wels (UCL MRC Unit for Lifelong Health & Ageing), writing in The Conversation. Like other countries, the UK implemented a number of initiatives to mitigate the effects of the COVID-19 pandemic on people's economic circumstances.

The law should take into consideration neuroscientific evidence that suggests fear and threat can cause victims to become 'frozen' in cases of rape or sexual assault, argue UCL experts. In a comment article, published in Nature Human Behaviour, Professor Patrick Haggard and former UCL undergraduate, Ebani Dhawan, state that victims of sexual assault are often blamed for not fighting or fleeing their attackers.

Climate change is likely to abruptly push species over tipping points as their geographic ranges reach unforeseen temperatures, finds a new study led by a UCL researcher. The new Nature Ecology & Evolution study predicts when and where climate change is likely to expose species across the globe to potentially dangerous temperatures.

Writing in The Conversation, Dr Jacques Wels (UCL MRC Unit for Lifelong Health & Ageing) shares his new research which found home working was not detrimental to mental health in the early stages of the pandemic, but was associated with negative effects later on. One of the key changes to our daily lives brought about by the COVID pandemic was, for those able to do so, working from home.

Humans inherited genetic material from Neanderthals that affects the shape of our noses, finds a new study led by UCL researchers. The new study finds that a particular gene, which leads to a taller nose (from top to bottom), may have been the product of natural selection as ancient humans adapted to colder climates after leaving Africa.

An estimated one million stillbirths and newborn baby deaths could be prevented each year by implementing low-cost pregnancy interventions in lowand middle-income countries, finds a new study involving UCL researchers. The new four-paper series, published in The Lancet , examined some of the most common causes of fetal growth restriction and preterm birth.

New population-based study led by UCL and the University of Oxford shows that autoimmune disorders are more common than previously thought. The research, published in The Lancet , estimates that around one in ten individuals in the UK now live with an autoimmune disorder. The findings also highlight important socioeconomic, seasonal and regional differences for several autoimmune disorders, providing new clues as to what factors may be involved in these conditions.

New research led by UCL and Great Ormond Street Hospital (GOSH) to predict which childhood leukaemia patients are at higher risk of not responding well to chemotherapy will allow clinicians to refine treatment strategies to give the best chance of success. The study, published in the Journal of Clinical Oncology , combined UK trial data from 2003-2019 to see which patients had worse outcomes.

Poorly monitored badger farming and illegal poaching in South Korea is a cause for concern for wildlife and human health, with regulation of the trade urgently needed, according to a new study involving UCL researchers. Published today in the Journal of Asia-Pacific Biodiversity, the study by researchers from UCL, Zoological Society London (ZSL) and Seoul National University, South Korea, found that a growing range of badger-derived products have been introduced to the market in South Korea over the last two decades.