A two-compartment mathematical model of neuroglial metabolism using [1-11C] acetate. Compared with 13C MRS studies, 11C radiotracer measurements provide a single uptake curve representing the sum of all labeled metabolites, without chemical differentiation, but with higher temporal resolution. The group of Rolf Gruetter (CIBM - Center for Biomedical Imaging ) propose in this study a two-compartment metabolic model of brain metabolism to assess oxidative metabolism from [1-11C] acetate radiotracer experiments, using an approach previously applied in 13C magnetic resonance spectroscopy (MRS), and compared with an one-tissue compartment model previously used in brain [1-11C] acetate studies. Bernard Lanz et al.,Journal of Cerebral Blood Flow & Metabolism; doi: 10.1038/jcbfm.2011.162 (2011)
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