Upper part: The DNA sensor cGAS (yellow) is activated upon binding DNA to produce a potent immunostimulatory molecule (red). Lower part: On intact genomic DNA cGAS (yellow) is bound by chromatin and inactivated to prevent auto-reactivity.
Upper part: The DNA sensor cGAS ( yellow ) is activated upon binding DNA to produce a potent immunostimulatory molecule ( red ). Lower part: On intact genomic DNA cGAS ( yellow ) is bound by chromatin and inactivated to prevent auto-reactivity. Digizyme - The Dr. Josef Steiner Cancer Research Award 2021, endowed with 1 million Swiss francs and originally referred to as the "Nobel Prize for Cancer Research", is awarded to Andrea Ablasser of the Swiss Federal Institute of Technology (EPFL) in Lausanne. In her work, she discovered new mechanisms by which the immune system recognizes viruses as foreign particles. Interestingly, these mechanisms also apply to cancer cells which behave similarly to viruses with regards to genetic instability and the capacity to evade detection by the immune system. The findings open new perspectives in cancer immunotherapy that may ultimately lead to the development of new therapeutic strategies. The Board of the Dr. Josef Steiner Cancer Foundation consisting of physiologists from the Universities of Bern, Geneva and Zürich has announced that Dr. Josef Steiner Cancer Research Award 2021 goes to Andrea Ablasser.
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