Bridget Murphy from the School of Biological Sciences.
A compound produced by a pregnant lizard may provide important information on the origins and treatment of cancer in humans, according to zoologist Bridget Murphy from the School of Biological Sciences who discovered the protein, which is pivotal to the development of the lizard placenta. "Our egg-laying ancestors probably never got cancer, but things changed when we started having live young. Embryos need an extensive network of blood vessels to allow them to grow. So do tumours. I found that the three-toed skink, which gives birth to live young, uses a particularly powerful protein to encourage the growth of blood vessels. The only other place where this protein has been found is in pre-cancerous cells grown in the laboratory," she says. Future research on unlocking the secrets of how the protein works might well provide the basis of new therapies for cancer, and to promote wound healing or the regeneration of blood vessels in patients with heart disease.
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