Eye test may detect Parkinson’s before symptoms appear

A new low-cost and non-invasive eye test could detect Parkinson's disease before symptoms including tremors and muscle stiffness develop, according to new research in rats led by scientists at UCL. Researchers at the UCL Institute of Ophthalmology have discovered a new method of observing changes in the retina which can be seen in Parkinson's before changes in the brain occur and the first symptoms become evident. Using ophthalmic instruments that are routinely used in optometrists and eye clinics, the scientists were able to use the new imaging technique to observe these retinal changes at an early stage. This method, published in Acta Neuropathologica , would allow earlier diagnosis of Parkinson's and also could be used to monitor how patients respond to treatment. The technique has already been tested in humans for glaucoma and trials are due to start soon for Alzheimer's. 'This is potentially a revolutionary breakthrough in the early diagnosis and treatment of one of the world's most debilitating diseases,' said Professor Francesca Cordeiro, UCL Professor of Glaucoma & Retinal Neurodegeneration Studies, who led the research. 'These tests mean we might be able to intervene much earlier and more effectively treat people with this devastating condition.' Parkinson's disease affects 1 in 500 people and is the second most common neurodegenerative disease worldwide.