© Claire Wilhelm / Laboratoire Matière et systèmes complexes (CNRS/Université Paris Diderot). The magnetic stretcher: this all-in-one system can both form and mechanically stimulate an aggregate of embryonic stem cells. The two micromagnets, one of which is mobile, frame the resulting embryonic body, and cyclical stimulation can be adapted to the type of tissue being sought.
By incorporating magnetic nanoparticles in cells and developing a system using miniaturized magnets, researchers at the Laboratoire Matière et Systèmes Complexes (CNRS/Université Paris Diderot), in collaboration with the Laboratoire Adaptation Biologique et Vieillissement (CNRS/UPMC) and the Centre de Recherche Cardiovasculaire de Paris (Inserm/Université Paris Descartes), have succeeded in creating cellular magnetic “Legos. They were able to aggregate cells using only magnets and without an external supporting matrix, with the cells then forming a tissue that can be deformed at will. This approach, which is detailed on , could prove to be a powerful tool for biophysical studies, as well as the regenerative medicine of tomorrow. Nanotechnology has quickly swept across the medical field by proposing sometimes unprecedented solutions at the furthest limits of current treatments, thereby becoming central to diagnosis and therapy, notably for the regeneration of tissue. A current challenge for regenerative medicine is to create a cohesive and organized cellular assembly without using an external supporting matrix. This is a particularly substantial challenge when it involves synthesizing thick and/or large-sized tissue, or when these tissues must be stimulated like their in vivo counterparts (such as cardiac tissue or cartilage) in order to improve their functionality. The researchers met this challenge by using magnetism to act on the cells at a distance, in order to assemble, organize, and stimulate them.
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