On the left, an expanded human cell with microtubules (blue) and a pair of centrioles (yellow-red) in the middle. On the right the detailed structure of two expanded pairs of centrioles. (Image: Fabian Zwettler / Uni Würzburg)
/2018 - Does expansion microscopy deliver true-to-life images of cellular structures' That was not sure yet. A new publication in "Nature Methods" shows for the first time that the method actually works reliably. Immersing deeper and deeper into cells with the microscope. Imaging the nucleus and other structures more and more accurately. Getting the most detailed views of cellular multi-protein complexes. All of these are goals pursued by the microscopy expert Markus Sauer at the Biocenter of Julius-Maximilians-Universität Würzburg (JMU) in Bavaria, Germany. Together with researchers from Geneva and Lausanne in Switzerland, he has now shown that a hitherto doubted method of super-resolution microscopy is reliable.
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