New genes identified in hearing loss, providing treatment hope

Researchers have identified 44 genes linked to age-related hearing loss, giving a much clearer understanding of how the condition develops, in a new study led by UCL and King's College London. In the study, published today in The  American Journal of Human Genetics , researchers analysed the genetic data from over 250,000 participants of the UK Biobank aged 40-69 years to see which genes were associated with people who had reported having or not having hearing problems on questionnaire. 44 genes were identified to be linked with hearing loss. Co-lead author Dr Sally Dawson (UCL Ear Institute) said: "Before our study, only five genes had been identified as predictors of age-related hearing loss, so our findings herald a nine-fold increase in independent genetic markers. "We hope that our findings will help drive forward research into much-needed new therapies for the millions of people worldwide affected by hearing loss as they age." By the age of 65, one third of people are affected by some degree of hearing loss which can lead to social isolation and disability and has been identified as a risk factor for dementia. Despite being a common impairment in the elderly, little is known about the causes of the hearing loss and the only treatment option available is hearing aids which are often not worn once prescribed. The findings of this study will allow researchers to determine how the condition develops as we age and may identify potential targets for new therapies.