Chromatin remodelers allow TF to access DNA by removing nucleosomes. This process is in a constant flux and can be compared to a revolving door. (See full picture in text).
Chromatin remodelers allow TF to access DNA by removing nucleosomes. This process is in a constant flux and can be compared to a revolving door. (See full picture in text) . Chromatin remodelers are needed to take nucleosomes away from DNA in order to make room for transcription factors to bind, and regulate the activity of our genes. It has been unclear how dynamic this process is. Researchers from the Schübeler group now revealed that active regulatory regions undergo continuous cycles of chromatin opening. Transcription factors (TFs) are proteins that help turn specific genes on or off by binding to nearby DNA.
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