During development, a pattern of chemical tags keeps specific genes quiet yet poised for action — like runners at the starting line.
During development, a pattern of chemical tags keeps specific genes quiet yet poised for action — like runners at the starting line. During development, scores of molecular signals prod cells to take on specialized identities and functions. In response to some of these signals, the cellular machinery awakens specific genes called 'immediate early genes' within minutes. The Rijli group has now identified a unique molecular signature that keeps immediate early genes quiet yet poised for rapid activation. Working out how immediate early genes are expressed at the right level in response to appropriate signals has important implications for our understanding of development, establishment of cell identity, and other key processes such as learning and memory formation in the brain. Chemical profile - Immediate early genes are expressed during development in several types of cells in response to growth factors and other signals. These genes often encode proteins called transcription factors that activate other genes.
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