Membrane Transporter Ensures Mobility of Sperm Cells

Newly discovered mechanism contributes to a better understanding of molecular foundations of fertility. Structure of the newly decoded protein found in the membrane of sperm cells. Colours mark the different units of the protein, which can be put together to make a functioning protein like the building blocks of a lego toy. Martin F. Peter - Special proteins - known as membrane transporters - are of key importance for the mobility of sperm cells. A research team from the Heidelberg University Biochemistry Center (BZH) headed by Cristina Paulino has, with the aid of cryo-electron microscopy, for the first time succeeded in decoding the structure of such a transporter and its mechanism. According to the researchers, these findings will enable a better understanding of the molecular foundations of reproductive capacity and could, in the long term, contribute to developing new approaches to treating fertility disorders and new methods of specific contraception. Sperm cells differ fundamentally in structure and function from other cell types.