The adult midgut of the Drosophila fly: The preparation is visible under the microscope due to nuclear staining and endogenous expression of the receptor Mayo. Photo: Beatriz Blanco-Redondo
The adult midgut of the Drosophila fly: The preparation is visible under the microscope due to nuclear staining and endogenous expression of the receptor Mayo. Photo: Beatriz Blanco-Redondo - Adhesion GPCRs are a group of G protein-coupled receptors associated with many bodily functions and diseases in humans. Scientists at Leipzig University have discovered a new receptor - which they have named "mayo" - and found that it influences the development of the small intestine and heart function in fruit flies, and that these phenomena may also be relevant in humans. Their findings have now been published in the journal Cell Reports. Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more. GPCRs translate stimuli that hit a cell from outside into an intracellular biochemical signal.
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