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A new X-ray imaging technique could transform how hospitals analyse tissue samples, potentially speeding up diagnoses and improving outcomes for patients, shows a new study led by UCL researchers. The technology, developed in collaboration with the Memorial Sloan Kettering Cancer Centre, Rigaku Americas and Creatv MicroTech, Inc., produces crisp 3D maps of biological tissue without cutting or staining samples, a significant improvement on the conventional process used in histopathology - the process of examining tissue to study, diagnose and treat diseases, particularly cancer.

Recent research shows that immune cells called B cells, previously overlooked, play an important role in juvenile idiopathic arthritis (JIA), explain Dr Lizzy Rosser and Dr Beth Jebson (both UCL Division of Medicine) in a new article for The Conversation. Arthritis  is often associated with older age, but it also affects children.

Scientists have successfully reconstructed videos purely from the brain activity of mice, showing what the mice were seeing, in a new study led by UCL researchers. The findings, published in eLife , could help shed light on the intricate workings of how the brain processes visual information and open new avenues for exploring how different species perceive the world.

A previously unknown chain of molecular signals that determines how strongly the body's immune system responds to viral infection has been discovered by scientists at UCL and the University of Cologne. Pattern recognition receptors act as sensors in the body's immune system that detect the molecular signatures of invading viruses and bacteria.

Weight loss drugs may help prevent further tissue damage following a heart attack, significantly reducing the risk of further life-threatening complications that affect up to half of all patients, finds a new study in mice led by UCL and University of Bristol researchers. Published in Nature Communications , the research suggests that GLP-1 mimicking weight loss drugs could offer a promising new therapeutic approach for improving heart attack recovery.

Scientists have found new clues about how the brains of people with Down syndrome develop differently from a very early age, in a study led by researchers at UCL and Queen Mary University of London. Brain cells with an extra copy of a chromosome (trisomy 21) - the genetic cause of Down syndrome - have difficulty forming strong, well-coordinated connections with each other, according to the new  Nature Communications study.

Pressure to achieve at school at age 15 is linked to depressive symptoms and risk of self-harm, and the association appears to persist into adulthood, finds a study led by UCL researchers. The authors of the new study, published in The Lancet Child & Adolescent Health , say their findings suggest that reducing academic pressure in schools could reduce depression and self-harm among young people.

Just over one in 10 deaths from a wide range of infectious diseases are associated with obesity worldwide, finds a major new study led by a UCL researcher. People with obesity face a 70% higher risk of hospitalisation or death from an infection than those of a healthy weight, suggest the findings published in The Lancet .

How does language impact moral dilemmas? Dr Irini Mavrou and Professor Andrea Revesz (both UCL Ioe), along with a colleague, explore the cognitive and emotional processes behind moral judgement by bilingual speakers. If you're bilingual, moral choices can often feel more urgent and emotionally charged in one language yet distant and rational in another.

Diabetes drugs that may soon be prescribed more widely in England could save thousands of lives each year, suggests a new study by researchers at UCL and the London School of Hygiene & Tropical Medicine (LSHTM). Last August the UK diabetes guideline committee at the National Institute for Health and Care Excellence (NICE) proposed SGLT-2 inhibitors alongside another drug, metformin, as a first-line treatment for people with type 2 diabetes.

A major study by UCL and Fondazione IRCCS Istituto Nazionale dei Tumori in Milan (INT) researchers has for the first time shown in detail how far children's cancer has spread at diagnosis in a way that can be compared between countries. While poorer survival following late-stage diagnosis is well recognised, the study is the first to show that differences in tumour stage at diagnosis may explain why childhood cancer survival varies between some European regions and tumour types.

In an article for the Institute of Alcohol Studies, Dr Sharon Cox (UCL Institute of Epidemiology & Health Care) reports on new analysis finding that one in eight people who drink at increasing or higher-risk levels felt guilt or remorse after drinking in the past six months. Many people recognise the feeling.

A team led by UCL researchers with Great Ormond Street Hospital (GOSH) and Moorfields Eye Hospital, found B cells-alongside T cells-play a key role in arthritis-related eye disease (JIA uveitis), a condition that can cause long-term vision loss in children. The study, funded by the Medical Research Foundation, Moorfields Eye Charity, Arthritis UK and Fight for Sight challenges how the disease has been previously understood, and could open the door to new treatments that help protect children's sight.

Dr Darío Moreno Agostino (UCL Institute of Education) outlines his research into the mental health of baby boomers and generation X throughout their adulthoods, revealing persistent gender and socioeconomic inequalities and increased distress levels during the pandemic. It's been almost five years since the end of the COVID lockdowns.

Memory dysfunction in Alzheimer's disease may be linked to impairment in how the brain replays our recent experiences while we are resting, according to a new study in mice by UCL scientists. The researchers say their findings, published in Current Biology , could help scientists develop drug treatments targeting this impaired brain function, or help design new tests for early diagnosis.

New research reveals how Parkinson's spreads from the gut to the brain, with the help of immune cells - offering a new potential therapeutic strategy - in a study in mice led by scientists at the UK Dementia Research Institute at UCL. Scientists have long theorised that Parkinson's may start in the gut.

Gentrifying neighbourhoods across London are undergoing rapid change, with rising numbers of newcomers arriving from less deprived areas and from further afield than ever before, according to new research from the Geographic Data Service led by a UCL researcher. The study, published by the charity Trust for London, shows that these areas are now driving a growing share of the capital's population churn, with far-reaching implications for housing pressures and who is able to live in the city.

Researchers at UCL and Great Ormond Street Hospital (GOSH) have developed the first-ever lab-grown mini-stomach that contains the key components of the full-sized human organ. Known as a multi-regional assembloid, the pea-sized mini-stomach is the first to contain the fundic region (the upper portion of the stomach), the body (the central region where food is mixed with acid and enzymes), and the antrum (the lower part of the stomach that breaks down food before entering the small intestine).

A remarkable prehistoric hammer made from elephant bone, dating back nearly half a million years ago, has been uncovered in southern England and analysed by archaeologists from UCL and the Natural History Museum, London. It is the oldest elephant bone tool to ever be discovered in Europe and provides an extraordinary glimpse into the ingenuity of the early human ancestors who made it.

Researchers at UCL have uncovered a key mechanism that helps the body switch off inflammation - a breakthrough that could lead to new treatments for chronic diseases affecting millions worldwide. Inflammation is the body's frontline defence against infection and injury, but when it doesn't switch off properly, it can drive serious health conditions such as arthritis, heart disease, and diabetes.