The drug molecules (red) are embedded in a water-filled cavity inside of the phospholipid vesicle.
Liposomes are currently used as drug delivery vehicles but recognized by the immune system. Scientists from the universities of Basel and Fribourg have shown that special artificial liposomes do not elicit any reaction in human and porcine sera as well as pigs. The study was published in the Journal Nanomedicine: Nanotechnology, Biology, and Medicine. Liposomes are soap-bubble-like nanocontainers made of a double phospholipid membrane that shields off an inner aqueous compartment. In a lenticular form, as developed by Professor Andreas Zumbühl's team at the Department of Chemistry at the University of Fribourg, they are promising candidates for drug delivery to constricted coronary arteries. Here, the blood flows through the stenosed artery segments with high velocity and is subjected to enhanced shear forces. Under these conditions, the liposomes open and release their content.
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