The core principle of this technology is the use of highly optimized sets of barcoded primers, the BRB-seq oligos. They are used to "tag" individual RNA samples in a unique and sample-specific manner. The oligos are optimized and validated to enable the generation of consistent, reproducible and uniform RNA sequencing data. (Source: Alithea Genomics)
The core principle of this technology is the use of highly optimized sets of barcoded primers, the BRB-seq oligos. They are used to "tag" individual RNA samples in a unique and sample-specific manner. The oligos are optimized and validated to enable the generation of consistent, reproducible and uniform RNA sequencing data. (Source: Alithea Genomics) - EPFL spin-off Alithea Genomics has developed a system that allows scientists to easily tag bulk RNA samples with molecular barcodes so they can be processed by the hundreds in one single tube. The technology promises to dramatically shorten and streamline sample preparation for RNA sequencing, which will enable new applications for this technology, such as biomarker discovery and drug development. RNA sequencing is becoming a key part of the process of developing new drugs and discovering biomarkers, which indicate the presence of certain diseases. Armed with a snapshot of RNA strands - the messengers that carry DNA information - scientists can gradually decode intracellular "language", detect anomalies and learn how to repair them.
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