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EPFL researchers propose a new approach of performing in vitro tests on nanoparticles that could enhance a correlation to in vivo results. This involves reproducing in the lab the dynamic and fluidic variations that these particles experience in the human body. Before new nanoparticles or other nanomedicines can be injected into the human body, a whole series of tests must be conducted in the laboratory, then in living cells, and in the end on humans. But often the results obtained in vitro do not resemble what actually happens in the animal or human body. Thus, the researchers reconsidered the basis of the in vitro experimental design. In an article published in the journal Small , EPFL researchers explain how such issues can be avoided by replacing conventional static in vitro tests with dynamic tests that approximate complex living conditions â?- comparable to those that occur in the bodyâ??s blood and lymphatic systems. The researchers were able to â?'replicateâ'' the varying real-body conditions in a lab, and test the behaviour of nanoparticles in different blood and lymph flows.
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