A673 cells treated with JTE-607 have increased nucleoplasmic R-loop formation. This works illustrates the impact of small molecules on modulating basic RNA processes in disease.’ Jeff Chao ’The contribution of the Chao group provided key mechanistic insights that were instrumental in bringing the study full circle. Felix Lohmann Research Overview Research Areas Scientific Publications Awards & Honors Partnerships Research Groups Overview Epigenetics Quantitative Biology Neurobiology Former Group Leaders Technology Platforms Overview C. elegans Facility Cell Sorting (FACS) Computional Biology Facility for Advanced Imaging and Microscopy Functional Genomics Proteomics & Protein Analysis Education & Careers Overview PhD & MD-PhD Programs Postdoctoral Activities Teaching Open Positions Working at the FMI Equality & Diversity Living in Basel Alumni About Overview FMI at a Glance Organization & Leadership Scientific Advisory Board History Contact News & Events Overview News Resources Seminars & Events 2019 © FMI Basel Switzerland About this site Extranet
Thanks to their expertise in single-molecule imaging of RNAs, researchers from the group of Jeff Chao at the FMI helped to reveal the biological mechanism of a small molecule that restricts Ewing's sarcoma cell growth. The study - published - is further evidence that each step of the gene expression pathway may be druggable, and a great example of a Novartis-FMI collaboration. Nearly twenty years ago, researchers became interested in a small molecule, called JTE-607, which seemed to play a role in inflammation and have a negative effect on acute myeloid leukemia (AML) cell lines. Despite the compound being tested in various preclinical disease models, its biological target and mode of action remained unknown. Employing a phenotypic screening approach, a group of researchers at the Novartis Institutes for BioMedical Research (NIBR) led by Nathan Ross, Felix Lohmann, and Rohan Beckwith discovered that in addition to certain forms of AML, Ewing's sarcoma cell lines were sensitive to JTE-607. This led to a comprehensive target identification effort that identified CPSF3 as the molecular target of JTE-607. CPSF3 is an enzyme that is critical for the processing of pre-mRNAs into mature transcripts.
TO READ THIS ARTICLE, CREATE YOUR ACCOUNT
And extend your reading, free of charge and with no commitment.
Your Benefits
- Access to all content
- Receive newsmails for news and jobs
- Post ads
