A ’humanised’ mouse model receives liver cells from healthy mice (control group) or human liver cells (humanised mice). The presence of human liver cells leads to a modification in the circadian clock of the liver and muscle and affects the central clock (the suprachiasmatic nuclei). This results in a phase advance in circadian rhythm in the humanised animal, the metabolism and behaviour of which shifts forward by a few hours.
A 'humanised' mouse model receives liver cells from healthy mice (control group) or human liver cells (humanised mice). The presence of human liver cells leads to a modification in the circadian clock of the liver and muscle and affects the central clock (the suprachiasmatic nuclei). This results in a phase advance in circadian rhythm in the humanised animal, the metabolism and behaviour of which shifts forward by a few hours. Luquet et al. Science Advances The liver could influence the body's central biological clock, a group of brain cells that influence most aspects of physiology and behaviour. Our liver plays a role in regulating our central biological clock, scientists from CNRS and Université Paris have discovered. The results of their study, published on 17 May in Science Advances, show that the biological clock of mice can be reprogrammed by inserting human liver cells into the animal's liver.
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